Ask the Expert Question:
We run several instruments like IC, ICP, GCMS, etc, for water analysis. What curve types are permitted (by EPA) to generate calibration curves. For example, EPA 300.1 ask for linear least squares fit. Can weighted models be use along with this?
Experts Response:
Tthe EPA method 300.1 does not allow any other calibration method other than linear regression. However, the EPA has been known to grant Alternative Test Protocol (ATP) status to use quadratic fit calibration models, but that is only granted on a case by case basis. You would need to apply for an ATP approval from EPA in order to use anything other than linear regression for method 300.1.
ICP, GCMS allow for linear regression models, as well as other calibration models. For GCMS it is most common to use Relative Percent Difference (RPD), weighted linear regression, and quadratic curves. I suggest that you read SW846 method 8000c for an explanation of the various calibration models acceptable for organic analysis.
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